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When rejetting a Q-Jet does proper jetting have an effect on reducing detonation?
I would think the major concern, as Bluedawg pointed out, that if the air/fuel ratio is too lean, you will be running hotter than necessary which promotes detonation, as well as your compression ratio. If your ratio is over 10.25:1, you may have to take steps that were not necessary before when you could buy higher than 91 octane. I run just fine on 91 octane with this ratio without having to back off timing. In fact, I am running at about 10 degrees advanced when factory called for 4. When I was jetting my carb, I never ran into detonation at all.
I hope that helps in some way.