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The Predator works well. The tune (for a Z06, all I have used it for) is safe and does provide a gain. The scanner is very useful. Their tech support helped me modify the tune provided for better results.
While a custom tune on a dyno is better, this really is pretty good. And you can go back to a stock tune without going to your tuner, helpful for a visit to the dealer.
Tons of controversy on this. I have one and am satisfied - was looking for improved driveablility, ability to go back to stock quickly for warranty purposes. It works well but as noted it is not as effective as a custom tune. I would still buy another given the level of mods (really just a cat back and CAI). If I was planning on headers and a intake, I would get a custom tune.