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I'm not an expert, but I would ask your tuner. Depends if you are using it more for cooling or octane. I run 80% methanol, my engine is n/a and i'm using it for an octane boost.
I think you will find 100% is what is recomended for the most power and cooling. That is what Julio and ECS said would work best for me with the stock LS3.
i got the kit from east coast supercharging and debating on driving there and having them tune it too. im not sure where else by me on long island to have it tuned. i know i can get it done but wonder if the best option is to bring it to them.
There's lots of info on this. Water cools faster with the 50/50. So you do get the Meth HP in crease with better cooling to the cylinders.
I have done both (100% meth on my C5) now 50/50 on my A&A SC C6.
Some will tell you to use 100% so you won't have to worry about mixing it with the water. My 2cent
When I had a C4 blown with Julio's kit, I tried a number of combinations. I stuck with 100% meth, seemed to be what worked best and it was also what Julio recommended. I found that I did not use a lot of meth. Bought it in 5 gallon cans and it usually lasted about a year, so cost was not an issue.
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It depends on WHY you added the alky kit.
Most add alky/meth for protection. In that case tune your engine WITHOUT the meth and then add it. In that case 50/50 will be more than enough but 100 will be more protection. Your call on how much protection you think you need.
If you add it for HP, personally, I'd tune it with 50/50 and run it with 100 ( just to be a little safe). The problem with tuning for 100% meth is that it will only take a little hiccup of the meth pump and your engine is toast.
Again, it's your call. How much protection do you want?