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Easy to do. I did it in my driveway in about 20 minutes. I burped it by letting it run with the cap off and installing coolant until it was at the correct level.
If you are fast enough you just remove the bolts and have the new stat at the ready, pull the housing back, remove old stat, drop in the new and button it back up while loosing minimal coolant. Just make sure you have the new stat clocked correctly.