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E85 is amazing. I feel gross everytime I have to fill up the C4 with 93 when I'm out on a road trip and don't know where E85 is. Luckily the flex fuel sensor takes care of the tune.
I add ~6 degrees with E85 compared to 93. E85 is magically boost food that is cheaper than pump gas.
The funny part is, absolutely NONE of my fuel system is E85 compatible and I haven't had a single issue in 3 years.
-Cheap ebay fuel cell with who knows what kind of foam.
-Twin AEM380 pumps that specifically say "greatly reduced life when used with E85"
-Summit Pushlok line, which is just cheap hydraulic hose.
-Whatever fuel filters I can find (typically diesel)
-Deka injectors that aren't rated for E85
-OEM fuel rails and regulator that aren't E85 rated.
I am swapping out the fuel lines, rail, regulator, and injectors this coming year, but only because I'm upgrading for more flow.
Alcohol is great. The oxygenation offered by E as well as its cooling properties (latent heat) is second to none. You just need a crap ton of system for it. If you're not running boost or not running a lot of it.... E isn't worth it imo. There are gains to be with it sure but it depends on the setup as I've said before, it really depends. It isn't magic, it depends on circumstances. I've seen plenty of guys gain one or two numbers and E isn't easy to come by around here at a pump. Meanwhile there are a few stations that still offer race gas out the pump.... actually about equal. If I had easy access, I'd build for it for sure.
And diesel parts are generally all compatible with E. They're chemically similar enough. Gasoline not so much. If it works for diesel it generally works for gas but not the other way around.