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I ran 3/4 of a tank of E85 and mixed it with a 1/4 tank of 93 and my car ran better than ever. The power was addicting as was the increased throttle response. The car just ran effortlessly. I'm wondering if anyone has run E85 for an extended period of time? I read the threads where people say not to run it because of corrosion, possible failed fuel pumps and that the manual forbids it. But we are not engineers and the manual might not be suggesting it because the car isn't tuned for it. The only real test is to run it long term and then look at the effect on fuel components. Lets see if anyone was brave or stupid enough to take this test. If I can find two or three people who have run it for two or more years with no ill effects I would go out an get a tune. I think the LS3 injectors can handle the task from what I read. Maybe get the plugs suggested for this tune.
Running E85 in a vehicle without a flex fuel sensor is very dangerous on a few levels. First your car's fuel system isn't rated to handle E85 which is very corrosive. Anything not rated for E85 will get eaten by it and can cause expensive repairs. Second, E85 requires ~30% more fuel to be added and since your car doesn't know you're using it you were probably running lean which you felt with the 'ol butt dyno. Yes lean is mean, but you don't want your computer clueless as to what you're doing and having no ideas what your A/F ratios are is going to cost you a motor.
If done right, E85 is a great fuel to run. I filled up at $2.79 on Saturday for what's essentially race fuel.