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I tune these all of the time. There are a few things to consider for the 2016 Z06.
The 2016 C7 Z06 low side fuel pump is one of the earlier models so you can't push it very far with the extra fuel volume required by Ethanol blends.
If you're not pushing the car hard and plan to leave it stock, you can likely run E30-E40, low side fuel limited, without adding a fuel booster or aux pump.
You will need a Flex Fuel sensor from DSX and have it pinned to the ECU
Not too hard but if you don't have the tools or the know how, its a bit of a PITA to get to the ECU in the Corvette.
Since you can't run full E85, you will need a way to monitor the E content and blend it at the pump.
We use Fuel-It Blue Tooth modules on all of our builds. It sends the ethanol content in your car right to your phone. No need to install a gauge.
You will need a tune to enable Flex Fuel and a tuner that knows how to tune for it on this platform.
If you do remote tuning, you will need HPTuners and a Laptop to work with a remote tuner.