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The rotating assy should be fine at 420 with an NA engine.
But 420 will be difficult with 9.2 compression ratio. You'll need to spin her about 6500+ RPM which means you'll need a cam in the 250 @ .50 range, which needs much more than 9.2
L-42. I'm adding Brodix Ik180's so it should bring my compression up to 9.2, but I don't really want to touch the bottom end so should I just run with thinner gasket to bump up compression?
And how long is my engine going to last with 2 bolt mains and 420 horses?
Depends on how much and how many times you want to use it!!
Seriously..the stock bottom end can handle 400-425 easily. The weak point will be cast pistons and make sure there is NO detonation. They won't last long that way.
I am interested in how this setup work out, too. Next year I would like to get my 1973 L-48 making 300 at the wheels and would rather not pull the engine. So if it can be done that'd be interesting.
As spec'd I saw 392HP@5500 with over 400TQ from 2500-5000 RPM...nice
Moving to the X274E cam took us to 402@6000 over 400TQ from 3000-5000 RPM. If you have the gears, it'd be worth looking at this cam or a retrofit roller if you have the cash.
IMHO, that's as far as that combo goes without more CR or even more cam...probably a retrofit roller. You'd need to make 440+ at the flywheel to get 350 at the rear wheels, using an 18% drivetrain loss (automatic).
Based on my experience, these are pretty realistic numbers - but all IMHO of course.