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I think what the other posts are trying to get at is that the motor mounts, transmission and transmission mounts, as well as the C-beam (connects to the tranny) would need to be modified or improvised. The ECM/Wiring harness wouldn't scare me much as I swapped those out in my 84 MPI conversion. but you may still lose certain dash readouts and whatnot depending on the year and features of your ride.
also, your fuel lines, air intake, coolant hoses, etc would all likely need to be tweaked with the installation of a completely different engine and accessory layout.