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I may be wrong here but in general octane rating has nothing to do with your MPG unless you are running the wrong gas.
Octane rating is just another word for how fast the fuel burns. The higher the octane the slower the burn. If the car is designed to run on 87 octane fuel running a higher octane could cause an incomplete fuel burn.
It is always best to run the octane rating that manufacture recommends unless you are running an aftermarket tune.
That is my understanding, too. Therefore, a question to OP: what is the recommended gas for your wife's car?