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The LT1 cam has different lobe profiles for the cylinders that deactivate, so you will need to change your cam if you intend to fully delete. I believe you have to use a factory LT5/ZR1 cam if you want to stay with the stock LT1 profile. No matter what, you will need a tune.
In the process of doing a full custom twin turbo kit now. He wants to get the bugs worked out on the stock motor then swap in a built unit. It would be nice if I could go ahead and delete the vvt and bulged front cover without swapping the cam. LME has a nice kit and they said it can be done as long as you tunes for it afterwards.